Glycation & AGE

A study undertaken in 2013 found that people aged between 50 -70 with high random blood sugars looked older than those with lower blood sugar and further more, people with diabetes and long-term high blood sugar looked older than non-diabetics. These results remained consistent even after taking into account other factors such as smoking, sun exposure and BMI.


Glycation is the non-enzymatic reaction between sugars and proteins, lipids or DNA. AGEs are Advanced Glycation End products. AGEs can be formed by eating high sugar, high fat foods and Reactive Oxygen Species (ROS) or free radicals can accelerate the process. AGEs formation increases with age, smoking, poor diet , UV radiation and pollution.

Study has mainly centered on the damage caused in the body such as Cataracts, Alzheimers and Parkinson’s but recently there has been increased interest in the role of AGEs in skin ageing.

Glycation contributes to the visible signs of ageing such as fine lines, wrinkles, discolouration and skin thinning. It does this by altering components of the skin both intracellularly and extracellularly, like proteins, lipids, fibroblasts and collagen causing their function to become impaired. The external signs of glycation are usually seen by age 35 .


AGEs not only exert their harmful actions directly, but also indirectly through their interaction with specific cell surface receptors.

When AGEs bind to these receptors it initiates a cascade of signals negatively influencing cell cycle and proliferation, gene expression, inflammation and ECM protein synthesis.

Receptor activation can directly induce oxidative stress and inflammation.

In addition to maintaining a healthy diet low in sugar and high in antioxidants it is important to use topical skincare products that specifically target glycation and AGEs.

LISA FRANKLIN products reduce the visible signs of ageing caused by free radicals, ROS, pollution and advanced glycation end products (AGEs).