A study undertaken in 2013 found that people between 50 -70 with high random blood sugars looked older than those with lower blood sugar and further that people with diabetes and long term high blood sugar looked older than non-diabetics. These results remained consistent even after taking into account other factors such as smoking, sun exposure and BMI.
WHAT IS GLYCATION and AGE
Glycation is the non-enzymatic reaction between sugars and proteins, lipids or DNA. AGEs are Advanced Glycation End products. AGEs can be formed by eating high sugar, high fat foods and Reactive Oxygen Species (ROS) or free radicals can accelerate the process. AGEs formation increases with age, smoking, poor diet , UV radiation and pollution.
Study has mainly centered on the damage caused in the body such as Cataracts, Alzheimers and Parkinson’s but recently there has been increased interest in the role of AGEs in skin ageing.
EFFECT of GLYCATION and AGEs on the SKIN
Glycation contributes to the visible signs of ageing such as fine lines, wrinkles, discolouration and skin thinning. It does this by altering components of the skin both intracellularly and extracellularly, like proteins, lipids, fibroblasts and collagen.
It affects proteins such as collagen causing it to become impaired, altered collagen inhibits new
synthesised collagen. The external signs of glycation are usually seen by age 35 .
ACTION of AGEs
AGEs not only exert their deleterious actions directly but also indirectly through their interaction with specific cell surface receptors.
When AGEs bind to these receptors it initiates a cascade of signals negatively influencing cell cycle and proliferation, gene expression, inflammation and ECM protein synthesis.
Receptor activation can directly induce oxidative stress and inflammation.
PREVENTING GLYCATION and AGE FORMATION.
In addition to maintaining a healthy diet low in sugar and high in antioxidants it is important to use skincare products that specifically target glycation and AGEs.
LISA FRANKLIN products reduce the visible signs of ageing caused by free radicals, ROS, pollution and advanced glycation end products.
Knotgrass extract protects the fibres of the dermis from UV and Infrared radiation preserving skin firmness. Specifically designed peptide complexes aid cell proliferation and differentiation, and re-establish the connections between the cell nucleus and the extra-cellular matrix (ECM). Kakadu Plum extract fights and protects against oxidative stress while Acmella extract reorganises the dermis structure.